Journal: Journal of neuroscience methods
Article Title: Animal studies in clinical MRI scanners: A custom setup for combined fMRI and deep-brain stimulation in awake rats.
doi: 10.1016/j.jneumeth.2021.109240
Figure Lengend Snippet: Fig. 10. DBS targeted at the dorsal part of the ventral striatum (dVS) induces a significantly higher percentage signal change compared to intermittent periods of no stimulation in the nucleus accumbens of awake rats. A significant dif ference in percentage signal change in the chosen ROI, the nucleus accumbens (NAc), was found when comparing the DBS ON periods with DBS OFF periods in a group of 6 awake rats. Signal intensity was extracted from the data using featquery (FMRIB Software Library 6.0) with the nucleus accumbens as ROI, from each animal, and the percentage signal change was calculated for DBS ON and the latter half of the DBS OFF periods relative to baseline. A paired sample t-test was performed on the percentages signal change of the DBS ON versus the DBS OFF periods. Mean + SD, *** - p = 0.001.
Article Snippet: Both implanted electrodes were connected to a digital stimulator (DS8000, World Precision Instruments, Berlin, Germany) through constant current digital linear stimulation isolators (DSL100, World Precision Instruments, Berlin, Germany) with carbon fiber wires (CPVC4050, 18 American wire gauge, 1.0 mm diameter, 3000 strands, World Precision Instruments, Berlin, Germany).
Techniques: Software